Charles White (1979)
At the University of Southern California, Charles White was a two-time Pac-12 Player of the year, and two-time consensus All-American. He led the nation in rushing in both 1978 (running for 1,859 yards) and 1979 (running for 2,050 yards), and won the Heisman in 1979. That led to the Cleveland Browns selecting White with a first round pick.
Unfortunately, during his first four seasons with the Browns, he struggled mightily, simultaneously battling substance issues. He did have a career year in 1987 as a member of the Los Angeles Rams, but outside of that one year when he ran for 1,374 yards, he ran for less than 350 yards in seven of the other eight seasons he played in the NFL.