2005. Aaron Rodgers (Pick: Alex Smith)
The San Francisco 49ers have nobody but themselves to blame for their terrible record in the 2000’s. After all, they were the franchise who passed on Aaron Rodgers, who went to school in the San Francisco Bay Area and rooted for the 49ers as a kid, to select quarterback Alex Smith.
As we all know, Rodgers has gone on to become one of the most dangerous and productive quarterbacks in NFL history, and will no doubt be enshrined in the Hall of Fame one day. In a rather terrible 2005 NFL Draft, the fact that Rodgers fell all the way to #24 overall really stands out.