2006. Mario Williams (Pick: Mario Williams)
The 2006 NFL Draft picked up right where the draft from the year before left off — not a lot of great choices, with the benefit of hindsight. While guys like Reggie Bush, Vince Young, and Matt Leonard were “can’t-miss” guys, it was defensive end Mario Williams — whom the Houston Texans famously selected with the #1 overall pick, over Bush — who finished with the most successful (albeit inconsistently so) career.
Interestingly enough, if you go back and look who might’ve been the second-best player in this draft, it was probably offensive tackle Andrew Whitworth, taken by the Cincinnati Bengals in the 2nd round.