4. EJ Manuel (2013, Pick #16)
In fairness to Erik Rodriguez “EJ” Manuel Jr., the Buffalo Bills screwed him over from the day he arrived in the NFL, because Manuel really had no business being a first-round pick in the 2013 NFL Draft. Manuel had all the physical tools you could ask for, but was miles away from being ready to contribute in the NFL.
Nonetheless, the hapless Bills franchise decided to push him into starting as a rookie, and the results were just about what you’d expect: marred with a few highs and a lot of lows. His 4-6 record wasn’t exactly anything to be inspired by, which is why he started 10 games as a rookie, only to see his number of starts decrease each of his four seasons in Buffalo.